Target Information

General Information of This Target
Target ID
PATR0YNDPC
Target Name
Farnesyl pyrophosphate synthase (FDPS)
Gene Name
FDPS
Gene ID
2224
Synonym
FPS, KIAA1293(2E,6E)-farnesyl diphosphate synthaseDimethylallyltranstransferaseFarnesyl diphosphate synthaseGeranyltranstransferase
Sequence
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK

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Family
the FPP/GGPP synthase family
Function
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

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Uniprot Entry
FPPS_HUMAN
HGNC ID
HGNC:3631
KEGG ID
hsa:2224
Full List of The ADC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
Tras-ALN
Trastuzumab
ERBB2
Alendronate
Bicyclo[6.1.0]nona-4-yne
 [1]
References
Ref 1 Harnessing the power of antibodies to fight bone metastasis. Sci Adv. 2021 Jun 23;7(26):eabf2051. doi: 10.1126/sciadv.abf2051.

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