Target Information

General Information of This Target
Target ID
PATR0XOETL
Target Name
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)
Gene Name
FKBP1A
Gene ID
2280
Synonym
FKBP1; FKBP12; PPIase FKBP1A; 12 kDa FK506-binding protein (12 kDa FKBP; FKBP-12); Calstabin-1; FK506-binding protein 1A (FKBP-1A); Immunophilin FKBP12; Rotamase
Sequence
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE

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Family
the FKBP-type PPIase family. FKBP1 subfamily
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

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Uniprot Entry
FKB1A_HUMAN
HGNC ID
HGNC:3711
KEGG ID
hsa:2280
Full List of The ADC Related to This Target
Terminated
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
CD184-tacrolimus antibody drug conjugate
Undisclosed
CXCR4
Tacrolimus
Undisclosed
 [1]
References
Ref 1 Ambrx biopharmaceutical company overview; 2014

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