Target Information

General Information of This Target

Target ID	PATR0UFYDR
Target Name	Dihydrofolate reductase (DHFR)
Gene Name	DHFR
Gene ID	1719
Sequence	MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF EVYEKND Click to Show/Hide
Family	the dihydrofolate reductase family
Function	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. Click to Show/Hide
Uniprot Entry	DYR_HUMAN
HGNC ID	HGNC:2861
KEGG ID	hsa:1719

Full List of The ADC Related to This Target

Investigative

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	B5-MTX	Anti-DLA-DR mAb B5	Leukocyte surface antigen CD47	Methotrexate	Undisclosed	[1]

Investigative(Terminated)

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	Monoclonal antibody 791T-36-methotrexate conjugate	791T-36	Complement decay-accelerating factor (CD55)	Methotrexate	Undisclosed	[2]

Phase 2

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	IGF-MTX	Anti-IGF1R mAb	Insulin-like growth factor 1 receptor (IGF1R)	Methotrexate	Undisclosed	[3]

References

Ref 1	An Antibody Specific for the Dog Leukocyte Antigen DR (DLA-DR) and Its Novel Methotrexate Conjugate Inhibit the Growth of Canine B Cell Lymphoma. Cancers (Basel). 2019 Sep 26;11(10):1438. doi: 10.3390/cancers11101438.
Ref 2	Biodistribution of a monoclonal antibody-methotrexate conjugate (791T/36-MTX) in patients with colorectal cancer. Int J Cancer Suppl. 1988;2:103-8. doi: 10.1002/ijc.2910410724.
Ref 3	IGF Oncology biotechnology company product pipeline