Target Information

General Information of This Target (ID: PATR0UFYDR)
Target Name
Dihydrofolate reductase (DHFR)
Gene Name
DHFR
Gene ID
1719
Sequence
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

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Family
the dihydrofolate reductase family
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.

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Uniprot Entry
DYR_HUMAN
HGNC ID
HGNC:2861
KEGG ID
hsa:1719
Full List of The ADC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
B5-MTX [1]
Anti-DLA-DR mAb B5
Dog leukocyte antigen DR (DLA-DR)
Methotrexate
Undisclosed
ADC Info
Investigative(Terminated)
Click To Hide/Show 1 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Monoclonal antibody 791T-36-methotrexate conjugate [2]
791T-36
Complement decay-accelerating factor (CD55)
Methotrexate
Undisclosed
ADC Info
Phase 2
Click To Hide/Show 1 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
IGF-MTX [3]
Anti-IGF1R mAb
Insulin-like growth factor 1 receptor (IGF1R)
Methotrexate
Undisclosed
ADC Info
References
Ref 1 An Antibody Specific for the Dog Leukocyte Antigen DR (DLA-DR) and Its Novel Methotrexate Conjugate Inhibit the Growth of Canine B Cell Lymphoma. Cancers (Basel). 2019 Sep 26;11(10):1438. doi: 10.3390/cancers11101438.
Ref 2 Biodistribution of a monoclonal antibody-methotrexate conjugate (791T/36-MTX) in patients with colorectal cancer. Int J Cancer Suppl. 1988;2:103-8. doi: 10.1002/ijc.2910410724.
Ref 3 IGF Oncology biotechnology company product pipeline