Target Information
General Information of This Target
Target ID | PATR0TYCUL |
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Target Name | Kinesin-like protein KIF11 (KIF11) |
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Gene Name | KIF11 |
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Gene ID | ||||||
Synonym | EG5; KNSL1; TRIP5; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5 |
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Sequence |
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL Click to Show/Hide
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Family | the TRAFAC class myosin-kinesin ATPas |
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Function |
Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface.
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Uniprot Entry | ||||||
HGNC ID | ||||||
KEGG ID |
Full List of The ADC Related to This Target
Clinical candidate
ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
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BAY-943 |
TPP-9476 |
IL3RA |
KSP inhibitor |
Protease cleavable linker |
[1] | |
BAY-924 |
Anti-CXCR5 IgG1 mAb |
CXCR5 |
KSP inhibitor |
Undisclosed |
[2] |
Investigative
ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
---|---|---|---|---|---|---|
TWEAKR-KSPi-ADC2 |
BAY-356 |
TNFRSF12A |
KSP inhibitor |
Mc-peptide-based linker |
[3] | |
TWEAKR-KSPi-ADC1 |
BAY-356 |
TNFRSF12A |
KSP inhibitor |
Glutaricacid-peptide-based linker |
[3] | |
TWEAKR ADC 3a |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3a |
Open-chain glycine maleimide |
[4] | |
TWEAKR ADC 3b |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3b |
Open-chain glycine maleimide |
[4] | |
TWEAKR ADC 3c |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3c |
Open-chain glycine maleimide |
[4] | |
TWEAKR ADC 3d |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3d |
Open-chain glycine maleimide |
[4] | |
TWEAKR ADC 3e |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3e |
Open-chain glycine maleimide |
[4] | |
TWEAKR ADC 3f |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3f |
Open-chain glycine maleimide |
[4] | |
TWEAKR ADC 3g |
BAY-356 |
TNFRSF12A |
Kinesin spindle protein (KSP) inhibitor 3g |
Open-chain glycine maleimide |
[4] | |
Anti-B7H3 APDC 3f |
TPP-8567 |
CD276 |
Kinesin spindle protein (KSP) inhibitor 3f |
Open-chain glycine maleimide |
[4] | |
Anti-B7H3 APDC 3g |
TPP-8567 |
CD276 |
Kinesin spindle protein (KSP) inhibitor 3g |
Open-chain glycine maleimide |
[4] | |
TWEAKR-KSP-ADC 1.1 |
Anti-TWEAKR mAb |
TNFRSF12A |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 1 |
[5] | |
TWEAKR-KSP-ADC 1.2 |
Anti-TWEAKR mAb |
TNFRSF12A |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 2 |
[5] | |
TWEAKR-KSP-ADC 1.3 |
Anti-TWEAKR mAb |
TNFRSF12A |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 3 |
[5] | |
TWEAKR-KSP-ADC 1.4 |
Anti-TWEAKR mAb |
TNFRSF12A |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 4 |
[5] | |
TWEAKR-KSP-ADC 2.1 |
Anti-TWEAKR mAb |
TNFRSF12A |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 5 |
[5] | |
TWEAKR-KSP-ADC 2.2 |
Anti-TWEAKR mAb |
TNFRSF12A |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 6 |
[5] | |
HER2 KSP-ADC 1.1 |
BAY-865 |
ERBB2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 1 |
[5] | |
HER2 KSP-ADC 1.2 |
BAY-865 |
ERBB2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 2 |
[5] | |
HER2 KSP-ADC 1.3 |
BAY-865 |
ERBB2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 3 |
[5] | |
HER2 KSP-ADC 1.4 |
BAY-865 |
ERBB2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 4 |
[5] | |
HER2 KSP-ADC 2.1 |
BAY-865 |
ERBB2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 5 |
[5] | |
HER2 KSP-ADC 2.2 |
BAY-865 |
ERBB2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 6 |
[5] |
References
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