Target Information

General Information of This Target
Target ID
PATR0SDXWL
Target Name
Geranylgeranyl pyrophosphate synthase (GGPS1)
Gene Name
GGPS1
Gene ID
9453
Synonym
(2E,6E)-farnesyl diphosphate synthaseDimethylallyltranstransferaseFarnesyl diphosphate synthaseFarnesyltranstransferaseGeranylgeranyl diphosphate synthaseGeranyltranstransferase
Sequence
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE

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Family
the FPP/GGPP synthase family
Function
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

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Uniprot Entry
GGPPS_HUMAN
HGNC ID
HGNC:4249
KEGG ID
hsa:9453
Full List of The ADC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
Cet-ZA ADC
Cetuximab
EGFR
Zoledronic acid
Undisclosed
 [1]
References
Ref 1 Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab. J Immunother Cancer. 2022 Dec;10(12):e005660.

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