Target Information
General Information of This Target
| Target ID | PATR0HBNVM |
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| Target Name | Arylamine N-acetyltransferase 2 (NAT2) |
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| Gene Name | NAT2 |
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| Gene ID | ||||||
| Synonym | AAC2; Arylamide acetylase 2; N-acetyltransferase type 2; Polymorphic arylamine N-acetyltransferase |
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| Sequence |
MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMELGLEAIFDHIV
RRNRGGWCLQVNQLLYWALTTIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTIDGRNYI VDAGSGSSSQMWQPLELISGKDQPQVPCIFCLTEERGIWYLDQIRREQYITNKEFLNSHL LPKKKHQKIYLFTLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILT YRKFNYKDNTDLVEFKTLTEEEVEEVLRNIFKISLGRNLVPKPGDGSLTI Click to Show/Hide
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| Family | the arylamine N-acetyltransferase family |
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| Function |
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
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Full List of The ADC Related to This Target
Investigative
| ADC Name | Antibody | Antigen | Payload | Linker | ADC Info |
|---|---|---|---|---|---|
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Anti-DR5 antibody-curcumin conjugate
[1]
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Anti-DR5 mAb |
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) |
Curcumin |
Mc-PEG-WDP |
References