Target Information

General Information of This Target
Target ID
PATR0HBNVM
Target Name
Arylamine N-acetyltransferase 2 (NAT2)
Gene Name
NAT2
Gene ID
10
Synonym
AAC2; Arylamide acetylase 2; N-acetyltransferase type 2; Polymorphic arylamine N-acetyltransferase
Sequence
MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMELGLEAIFDHIV
RRNRGGWCLQVNQLLYWALTTIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTIDGRNYI
VDAGSGSSSQMWQPLELISGKDQPQVPCIFCLTEERGIWYLDQIRREQYITNKEFLNSHL
LPKKKHQKIYLFTLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILT
YRKFNYKDNTDLVEFKTLTEEEVEEVLRNIFKISLGRNLVPKPGDGSLTI

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Family
the arylamine N-acetyltransferase family
Function
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

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Uniprot Entry
ARY2_HUMAN
HGNC ID
HGNC:7646
KEGG ID
hsa:10
Full List of The ADC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
Anti-DR5 antibody-curcumin conjugate
Anti-DR5 mAb
TNFRSF10B
Curcumin
Mc-PEG-WDP
 [1]
References
Ref 1 An anti-DR5 antibody-curcumin conjugate for the enhanced clearance of activated hepatic stellate cells. Int J Biol Macromol. 2021 Dec 1;192:1231-1239. doi: 10.1016/j.ijbiomac.2021.09.176. Epub 2021 Oct 6.

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