Target Information

General Information of This Target
Target ID
PATR0EDEOX
Target Name
Bcl-2-like protein 1 (BCL2L1)
Gene Name
BCL2L2; BCLW; KIAA0271
Gene ID
599
Synonym
BCLW; KIAA0271
Sequence
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG
QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL
GALVTVGAFFASK

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Family
Bcl-2 family
Function
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.

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Uniprot Entry
B2CL2_HUMAN
HGNC ID
HGNC:995 ; HGNC:42959
KEGG ID
hsa:599
Full List of The ADC Related to This Target
Phase 1
Click To Hide/Show 2 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
Mirzotamab clezutoclax
Mirzotamab
B7-H3
Clezutoclax
Val-Ala dipeptide linker
ADC Info
ABBV-637
Anti-EGFR antibody
EGFR
BCL-xL inhibitor
Undisclosed