Payload Information
General Information of This Payload
| Payload ID | PAY0ZYBPL |
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|---|---|---|---|---|---|---|
| Name | Porphyrin (Por)-tetrazine (Tz) |
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| Synonyms |
porphyrin (Por)-tetrazine (Tz)
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| Formula | C44H30N4 |
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| Isosmiles | C(/C(N1)=CC=C1/C(C2=CC=CC=C2)=C3C=CC4=N/3)(C5=CC=CC=C5)=C6C=CC(/C(C7=CC=CC=C7)=C(N/8)/C=CC8=C4/C9=CC=CC=C9)=N\6 |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C44H30N4/c1-5-13-29(14-6-1)41-33-21-23-35(45-33)42(30-15-7-2-8-16-30)37-25-27-39(47-37)44(32-19-11-4-12-20-32)40-28-26-38(48-40)43(31-17-9-3-10-18-31)36-24-22-34(41)46-36/h1-28,45,48H
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| InChIKey |
YNHJECZULSZAQK-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
614.752 |
Polar area |
57.36 |
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Complexity |
2154.254411 |
xlogp Value |
11.3236 |
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Heavy Count |
48 |
Rot Bonds |
4 |
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Hbond acc |
2 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Cellular activity | 100 | % |
HaCaT cells
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Normal
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| Cellular activity | 43.3 | % | Undisclosed | Undisclosed | Undisclosed | |
| Cellular activity | 50 | % | Undisclosed | Undisclosed | Undisclosed | |
| Cellular activity | 52 | % | Undisclosed | Undisclosed | Undisclosed | |
| Cellular activity | 63 | % | Undisclosed | Undisclosed | Undisclosed | |
| Cellular activity | 64 | % | Undisclosed | Undisclosed | Undisclosed | |
| Cellular activity | 84.2 | % | Undisclosed | Undisclosed | Undisclosed | |
| Cellular activity | 95.1 | % | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | >50000 | nM | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | >50000 | nM | Undisclosed | Undisclosed | Undisclosed |
Each Antibody-drug Conjugate Related to This Payload