Payload Information
General Information of This Payload
| Payload ID | PAY0ZXOON |
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|---|---|---|---|---|---|---|
| Name | Nostocyclopeptide-1 |
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| Synonyms |
Nostocyclopeptide-1
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| Structure |
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| Formula | C46H66ClN5O7S |
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| Isosmiles | C[C@H]([C@@H]1[C@H](O1)C2=CC=C(CN3CCN(CC3)CCC(C)(S)C)C=C2)[C@@H](OC([C@@H](NC(C(C)(C)CN4)=O)CC(C)C)=O)C/C=C/C(N[C@@H](C4=O)CC5=CC=C(OC)C(Cl)=C5)=O |
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| InChI |
InChI=1S/C46H66ClN5O7S/c1-29(2)24-36-43(55)58-37(30(3)40-41(59-40)33-15-12-31(13-16-33)27-52-22-20-51(21-23-52)19-18-46(6,7)60)10-9-11-39(53)49-35(26-32-14-17-38(57-8)34(47)25-32)42(54)48-28-45(4,5)44(56)50-36/h9,11-17,25,29-30,35-37,40-41,60H,10,18-24,26-28H2,1-8H3,(H,48,54)(H,49,53)(H,50,56)/t30-,35+,36-,37-,40+,41+/m0/s1
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| InChIKey |
XYHIRUMIFCUCBH-ZSLYCBLHSA-N
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| Pharmaceutical Properties | Molecule Weight |
868.582 |
Polar area |
141.84 |
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Complexity |
1756.481175 |
xlogp Value |
5.9132 |
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Heavy Count |
60 |
Rot Bonds |
13 |
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Hbond acc |
10 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
MORAb-003 ADC1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.41 nM
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High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||