Payload Information
General Information of This Payload
| Payload ID | PAY0ZHUCR |
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|---|---|---|---|---|---|---|
| Name | Payload 1569 |
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| Synonyms |
1569
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| Structure |
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| Formula | C11H22N2O3 |
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| Isosmiles | CC(C(N[C@@H](C(C)C)C(O)=O)=O)(N(C)C)C |
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| InChI |
InChI=1S/C11H22N2O3/c1-7(2)8(9(14)15)12-10(16)11(3,4)13(5)6/h7-8H,1-6H3,(H,12,16)(H,14,15)/t8-/m0/s1
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| InChIKey |
FZCNDFZBOKDBHH-QMMMGPOBSA-N
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| Pharmaceutical Properties | Molecule Weight |
230.308 |
Polar area |
69.64 |
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Complexity |
253.211876 |
xlogp Value |
0.552 |
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Heavy Count |
16 |
Rot Bonds |
5 |
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Hbond acc |
3 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half maximal Inhibitory Concentration (IC50) | 0.074 | nM |
HT29 cells
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Colon cancer
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[1] | |
| Half maximal Inhibitory Concentration (IC50) | 0.074 | nM |
HT29 cells
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Colon cancer
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[1] | |
| Half maximal Inhibitory Concentration (IC50) | 0.269 | nM |
WI38-VA13 cells
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Normal
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[1] | |
| Half maximal Inhibitory Concentration (IC50) | 0.269 | nM |
WI38-VA13 cells
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Normal
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[1] |
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
EDB-L19-diS-C2OCO-1569 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5 ng/mL
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Negative EDB expression (EDB-) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.4 (IDBS)
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| In Vitro Model | Colon cancer | HT29 cells | CVCL_A8EZ | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
21 ng/mL
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Positive EDB expression (EDB+++/++) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.3 (IDBS)
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| In Vitro Model | Normal | WI38-VA13 cells | CVCL_2759 | ||
EDB-L19-vc-1569 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
40 ng/mL
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Positive EDB expression (EDB+++/++) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.11 (IDBS)
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| In Vitro Model | Normal | WI38-VA13 cells | CVCL_2759 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5702 ng/mL
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Negative EDB expression (EDB-) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.12 (IDBS)
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| In Vitro Model | Colon cancer | HT29 cells | CVCL_A8EZ | ||