Payload Information
General Information of This Payload
| Payload ID | PAY0XPRTH |
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| Name | US12209180B2 AM1 |
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| Synonyms |
AM1
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
AbA_D265C_LALA_H435A-AM1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.012 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro PBMC killing assays: ADCs conjugated to AM1
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| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.023 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro PBMC killing assays: ADCs conjugated to AM1
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| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.36 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell line killing assays
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| In Vitro Model | B acute lymphoblastic leukemia | Reh cells | CVCL_1650 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.372 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro BM HSC killing assay: ADCs conjugated to AM1 or PBD
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| In Vitro Model | Bone marrow hematopoietic stem cells | BM HSC cells (CD34+CD90+) | Homo sapiens | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.71 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell killing assays: ADCs conjugated to AM1, AM2, or PBD
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| In Vitro Model | B acute lymphoblastic leukemia | Reh cells | CVCL_1650 | ||
| Experiment 6 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
1.1 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell line killing assays
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| In Vitro Model | T acute lymphoblastic leukemia | Jurkat cells | CVCL_0065 | ||
| Experiment 7 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
1.365 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell line killing assays
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| In Vitro Model | Adult acute myeloid leukemia | SKNO-1 cells | CVCL_2196 | ||
AbC_D265C_LALA_H435A-AM1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.065 nM
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Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell killing assays: ADCs conjugated to AM1, AM4, or PBD
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| In Vitro Model | B acute lymphoblastic leukemia | Reh cells | CVCL_1650 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) |
0.42 nM
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Positive CD45,AbC expression (CD45,AbC +++/++) | ||
| Method Description |
In vitro cell killing assays: ADCs conjugated to AM1, AM4, or PBD
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| In Vitro Model | B acute lymphoblastic leukemia | Reh cells | CVCL_1650 | ||