Payload Information
General Information of This Payload
| Payload ID | PAY0XJJGM |
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|---|---|---|---|---|---|---|
| Name | PSMA-HC41-LD64 payload |
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| Synonyms |
PAY0419
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| Structure |
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| Formula | C29H23ClN4O5 |
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| Isosmiles | CC1=C2C([C@@H](CN3C(C4=CN5C=C(NC(C6=CC=C(O)C=C6)=O)C=CC5=N4)=O)CCl)=C3C=C(O)C2=CC=C1.[O] |
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| InChI |
InChI=1S/C29H23ClN4O4.O/c1-16-3-2-4-21-24(36)11-23-27(26(16)21)18(12-30)13-34(23)29(38)22-15-33-14-19(7-10-25(33)32-22)31-28(37)17-5-8-20(35)9-6-17;/h2-11,14-15,18,35-36H,12-13H2,1H3,(H,31,37);/t18-;/m1./s1
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| InChIKey |
PDLAHSZRKWJITB-GMUIIQOCSA-N
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| Pharmaceutical Properties | Molecule Weight |
542.979 |
Polar area |
135.67 |
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Complexity |
1703.409868 |
xlogp Value |
5.32342 |
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Heavy Count |
39 |
Rot Bonds |
4 |
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Hbond acc |
6 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
PSMA-HC41-LD64 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
2.07 nM
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Positive PSMA expression (PSMA +++/++) | ||
| Method Description |
In vitro cytotoxicity of anti-PSMA ADCs in human tumour cells expressing PSMAPSMA-positive cell line LNCaP-C4.2
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| In Vitro Model | Prostate carcinoma | LNCaP-C4.2 cells | CVCL_4782 | ||