Payload Information
General Information of This Payload
| Payload ID | PAY0WZNEJ |
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| Name | Dolicatatin 3 |
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| Synonyms |
Dolicatatin 3
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| Structure |
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| Formula | C42H70N6O9S |
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| Isosmiles | C[C@H](C(N(C)C([C@@H](NC([C@@H](NC)C(C)C)=O)C(C)C)=O)[C@H](OC)CC(N1CCC[C@H]1[C@H](OC)[C@H](C(N[C@H](C(NS(C2CC2)(=O)=O)=O)CC3=CC=CC=C3)=O)C)=O)CC |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C42H70N6O9S/c1-12-27(6)37(47(9)42(53)36(26(4)5)45-41(52)35(43-8)25(2)3)33(56-10)24-34(49)48-22-16-19-32(48)38(57-11)28(7)39(50)44-31(23-29-17-14-13-15-18-29)40(51)46-58(54,55)30-20-21-30/h13-15,17-18,25-28,30-33,35-38,43H,12,16,19-24H2,1-11H3,(H,44,50)(H,45,52)(H,46,51)/t27-,28+,31-,32-,33+,35-,36-,37?,38+/m0/s1
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| InChIKey |
QYDQCJXSAVVWJY-DQZODXLJSA-N
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| Pharmaceutical Properties | Molecule Weight |
835.122 |
Polar area |
192.55 |
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Complexity |
1570.864661 |
xlogp Value |
2.6274 |
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Heavy Count |
58 |
Rot Bonds |
23 |
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Hbond acc |
10 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
MORAb-003 ADC12 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||
MORAb-003 ADC14 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 500 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||