Payload Information
General Information of This Payload
| Payload ID | PAY0WEFFZ |
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| Name | BGA0084 Payload |
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| Synonyms |
BGA0084 Payload
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| Structure |
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| Formula | C28H27F2N3O6 |
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| Isosmiles | CC[C@]1(O)C(C=C2C3=NC(C=C4F)=C5C([C@@H](NC([C@](F)(CO)C)=O)CCC5=C4C)=C3CN26)=C(COC1=O)C6=O |
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| InChI |
InChI=1S/C28H27F2N3O6/c1-4-28(38)16-7-20-23-14(9-33(20)24(35)15(16)10-39-26(28)37)22-18(32-25(36)27(3,30)11-34)6-5-13-12(2)17(29)8-19(31-23)21(13)22/h7-8,18,34,38H,4-6,9-11H2,1-3H3,(H,32,36)/t18-,27+,28-/m0/s1
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| InChIKey |
SJQLZGZXXZBMJQ-GGQWNLSXSA-N
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| Pharmaceutical Properties | Molecule Weight |
539.535 |
Polar area |
130.75 |
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Complexity |
1631.464712 |
xlogp Value |
2.35112 |
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Heavy Count |
39 |
Rot Bonds |
4 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
BGA0084 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.19 nM
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Positive CEA expression (CEA+++/++) | ||
| Method Description |
NCI-H2122 cells were plated at a density of 2000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Lung adenocarcinoma | NCI-H2122 cells | CVCL_1531 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.38 nM
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Positive CEA expression (CEA+++/++) | ||
| Method Description |
MKN45 cells were plated at a density of 5000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Gastric adenocarcinoma | MKN45 cells | CVCL_0434 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.85 nM
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Positive CEA expression (CEA+++/++) | ||
| Method Description |
Ls147T cells were plated at a density of 5000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Colon adenocarcinoma | Ls147T cells | CVCL_1384 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
25 nM
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Negative CEA expression (CEA-) | ||
| Method Description |
MDA-MB-231 cells were plated at a density of 2000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-231 cells | CVCL_0062 | ||