Payload Information

General Information of This Payload (ID: PAY0WCNDB)
Name
I030
Target IKZF1/3
 Target Info 
Structure
Isosmiles
O=C1NC(CCC1N(C(C2=CC=CC3=C42)=O)C4=CC=C3CC5=CN(C6CCNCC6)N=C5)=O
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Half Maximal Inhibitory Concentration (IC50) 0.16 nM
NCI-H929 cells
Multiple myeloma
CVCL_1600 
Half Maximal Degradation Concentration (DC50) 0.256 nM
MM.1S cells
Multiple myeloma
CVCL_8792 
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
Dara-DVA-I030 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.142 nM
In Vitro Model Plasma cell myeloma NCI-H929 cells CVCL_1600
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.385 nM
In Vitro Model Plasma cell myeloma, Multiple myeloma MM.1S cells CVCL_8792
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) > 10 nM
In Vitro Model Normal PBMC cells CVCL_0140
Belan-DVA-I030 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.237 nM
In Vitro Model Plasma cell myeloma NCI-H929 cells CVCL_1600
References
Ref 1 Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy