Payload Information
General Information of This Payload
| Payload ID | PAY0WCMYD |
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|---|---|---|---|---|---|---|
| Name | Budesonide derivative P12 |
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| Synonyms |
Budesonide derivative P12
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| Target(s) | Glucocorticoid receptor (NR3C1) | |||||
| Structure |
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| Formula | C30H35F2NO6 |
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| Isosmiles | CCCC1OC2CC3C4CC(F)C5=CC(=O)C=CC5C4(F)C(O)CC3(C)C2(C(=O)COc2ccc(N)cc2)O1 |
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| InChI |
InChI=1S/C30H35F2NO6/c1-3-4-27-38-26-13-21-22-12-23(31)19-11-17(34)7-10-20(19)29(22,32)24(35)14-28(21,2)30(26,39-27)25(36)15-37-18-8-5-16(33)6-9-18/h5-11,20-24,26-27,35H,3-4,12-15,33H2,1-2H3
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| InChIKey |
RIHJSCKAWDPKDQ-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
543.607 |
Polar area |
108.08 |
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Complexity |
39 |
xlogp Value |
4.0357 |
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Heavy Count |
39 |
Rot Bonds |
6 |
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Hbond acc |
7 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half-maximal effective concentration (EC50) | 0.11 | nM (72h) |
HEK293 cells
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Normal
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[1] | |
| Half-maximal effective concentration (EC50) | 0.18 | nM (48h) |
HEK293 cells
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Normal
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 2.3 | nM |
HEK293 cells
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Normal
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[1] |
Each Antibody-drug Conjugate Related to This Payload
References
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