Payload Information
General Information of This Payload
| Payload ID | PAY0VXADA |
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| Name | CN118001423A+ADC1+payload |
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| Synonyms |
CN118001423A+ADC1+payload
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| Structure |
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| Formula | C33H30F2N4O8 |
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| Isosmiles | CC[C@]1(O)C(C=C2C3=NC4=CC5=C(OCO5)C=C4C(CCN(C(OCC6=CC=C(N)C=C6)=O)CC(F)F)=C3CN72)=C(COC1=O)C7=O |
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| InChI |
InChI=1S/C33H30F2N4O8/c1-2-33(43)23-10-25-29-21(12-39(25)30(40)22(23)15-44-31(33)41)19(20-9-26-27(47-16-46-26)11-24(20)37-29)7-8-38(13-28(34)35)32(42)45-14-17-3-5-18(36)6-4-17/h3-6,9-11,28,43H,2,7-8,12-16,36H2,1H3/t33-/m0/s1
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| InChIKey |
JRLLJXDMNHXSCQ-XIFFEERXSA-N
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| Pharmaceutical Properties | Molecule Weight |
648.619 |
Polar area |
155.44 |
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Complexity |
1937.57455 |
xlogp Value |
3.8369 |
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Heavy Count |
47 |
Rot Bonds |
8 |
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Hbond acc |
11 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
CN118001423A ADC1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
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| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
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| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
References