Payload Information
General Information of This Payload
| Payload ID | PAY0VLUAJ |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 41 payload |
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| Synonyms |
PAY0465
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| Structure |
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| Formula | C59H68N12O9 |
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| Isosmiles | CN1C(C2=C(C(C(C=CC3=NC(N4CCC(N5CCC(C)(NCC#CC6=CC=C(OC)C(N(C7=O)CCC(N7CNC([C@@H](NC(C)=O)CC(N)=O)=O)=O)=C6)CC5)CC4)=N8)=CC3=C8[C@](CO)(OC9CC9)C%10=CC=CC=C%10)=C1)C=CN2)=O |
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| InChI |
InChI=1S/C59H68N12O9/c1-37(73)64-47(33-50(60)74)54(76)62-36-71-51(75)21-28-70(57(71)78)48-31-38(12-17-49(48)79-4)9-8-24-63-58(2)22-29-68(30-23-58)41-19-26-69(27-20-41)56-65-46-16-13-39(45-34-67(3)55(77)52-43(45)18-25-61-52)32-44(46)53(66-56)59(35-72,80-42-14-15-42)40-10-6-5-7-11-40/h5-7,10-13,16-18,25,31-32,34,41-42,47,61,63,72H,14-15,19-24,26-30,33,35-36H2,1-4H3,(H2,60,74)(H,62,76)(H,64,73)/t47-,59+/m0/s1
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| InChIKey |
AXMYUPFTKJXNRN-INOXBNOZSA-N
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| Pharmaceutical Properties | Molecule Weight |
1089.268 |
Polar area |
262.68 |
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Complexity |
3358.602169 |
xlogp Value |
3.9774 |
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Heavy Count |
80 |
Rot Bonds |
18 |
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Hbond acc |
15 |
Hbond Donor |
6 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 41 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.038 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||