Payload Information
General Information of This Payload
| Payload ID | PAY0SBZEY |
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| Name | WO2024140449A1+ADC17+payload |
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| Synonyms |
WO2024140449A1+ADC17+payload
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| Structure |
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| Formula | C28H29N3O7 |
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| Isosmiles | O=C1C(COC2=O)=C([C@]2(CC)O)C=C3C4=NC5=CC6=C(OCO6)C=C5C(CCNC7CCOCC7)=C4CN13 |
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| InChI |
InChI=1S/C28H29N3O7/c1-2-28(34)20-10-22-25-18(12-31(22)26(32)19(20)13-36-27(28)33)16(3-6-29-15-4-7-35-8-5-15)17-9-23-24(38-14-37-23)11-21(17)30-25/h9-11,15,29,34H,2-8,12-14H2,1H3/t28-/m0/s1
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| InChIKey |
NDSZNBBWCPDPNV-NDEPHWFRSA-N
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| Pharmaceutical Properties | Molecule Weight |
519.554 |
Polar area |
121.14 |
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Complexity |
1501.751089 |
xlogp Value |
2.1194 |
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Heavy Count |
38 |
Rot Bonds |
5 |
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Hbond acc |
10 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
wO2024140449A1 ADC18 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test onNCI-H1975
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| In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||