Payload Information
General Information of This Payload
| Payload ID | PAY0RBKOC |
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| Name | AU2020291014A1-Payload-35 |
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| Synonyms |
AU2020291014A1-Payload-35
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| Structure |
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| Formula | C32H44N6O5S |
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| Isosmiles | CCCN(CCCNC(OC(C)(C)C)=O)C(C(CC(N)=N1)=CC2=C1C=C(C=C2)C3=CC(S(=O)(N4CC(CN)C4)=O)=CC=C3)=O |
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| InChI |
InChI=1S/C32H44N6O5S/c1-5-13-37(14-7-12-35-31(40)43-32(2,3)4)30(39)26-15-25-11-10-24(17-28(25)36-29(34)18-26)23-8-6-9-27(16-23)44(41,42)38-20-22(19-33)21-38/h6,8-11,15-17,22H,5,7,12-14,18-21,33H2,1-4H3,(H2,34,36)(H,35,40)
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| InChIKey |
AGTAMUSEEHZEPM-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
624.808 |
Polar area |
160.42 |
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Complexity |
1487.24951 |
xlogp Value |
3.862 |
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Heavy Count |
44 |
Rot Bonds |
11 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
AU2020291014A1 IC-23 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
464 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||