Payload Information
General Information of This Payload
| Payload ID | PAY0RBGYB |
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|---|---|---|---|---|---|---|
| Name | Budesonide derivative P3 |
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| Synonyms |
Budesonide derivative P3
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| Target(s) | Glucocorticoid receptor (NR3C1) | |||||
| Structure |
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| Formula | C25H33F2NO5 |
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| Isosmiles | CCCC1OC2CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(C(=O)CN)O1 |
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| InChI |
InChI=1S/C25H33F2NO5/c1-4-5-21-32-20-10-14-15-9-17(26)16-8-13(29)6-7-22(16,2)24(15,27)18(30)11-23(14,3)25(20,33-21)19(31)12-28/h6-8,14-15,17-18,20-21,30H,4-5,9-12,28H2,1-3H3
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| InChIKey |
HQWBIRXSESNHLR-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
465.537 |
Polar area |
98.85 |
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Complexity |
33 |
xlogp Value |
2.7233 |
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Heavy Count |
33 |
Rot Bonds |
4 |
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Hbond acc |
6 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half-maximal effective concentration (EC50) | 1.17 | nM (48 h) |
HEK293 cells
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Normal
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[1] | |
| Half-maximal effective concentration (EC50) | 1.59 | nM (72 h) |
HEK293 cells
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Normal
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 7.34 | nM |
HEK293 cells
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Normal
|
[1] |
Each Antibody-drug Conjugate Related to This Payload
References
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