Payload Information

General Information of This Payload

Payload ID	PAY0PSYAB
Name	NeoDegrader P14
Synonyms	NeoDegrader P14 Click to Show/Hide
Target(s)	Protein cereblon (CRBN)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Anti-CD33 AB1 Compound (Ik) [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 16.60% (Day 16)	Positive CD33 expression (CD33+++/++)
Method Description	1 x 10⁷ MV411 human acute monocytic leukemia cells in 50% Matrigel were injected subcutaneously in the flank of the mice (0.1 mL/mouse). The mice were dosed with anti-CD33 antibody-neoDegrader conjugates and vehicle control once tumors reached an average size of 100-150 mm³. The stock solutions of CD33AB-Compound (lb) was diluted with vehicle, which provided, 3.86 mg/kg in a dosing volume of 10 mL/kg (0.2 mL per 20 g mouse). Click to Show/Hide
In Vivo Model	MV411 CDX model
In Vitro Model	Childhood acute monocytic leukemia	MV4-11 cells		CVCL_0064

References

Ref 1	Pyrrolobenzodiazepines and conjugates thereof; 2013-04-18.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.