Payload Information
General Information of This Payload
| Payload ID | PAY0PQSSO |
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| Name | AU2020291014A1-Payload-70 |
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| Synonyms |
AU2020291014A1-Payload-70
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| Formula | C27H35N5O3S |
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| Isosmiles | CCCN(CCC)C(C(CC(N)=N1)=CC2=C1C=C(C=C2)C3=CC(S(=O)(N4CC(CN)C4)=O)=CC=C3)=O |
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| InChI |
InChI=1S/C27H35N5O3S/c1-3-10-31(11-4-2)27(33)23-12-22-9-8-21(14-25(22)30-26(29)15-23)20-6-5-7-24(13-20)36(34,35)32-17-19(16-28)18-32/h5-9,12-14,19H,3-4,10-11,15-18,28H2,1-2H3,(H2,29,30)
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| InChIKey |
SXOMOVUYILFVGI-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
509.676 |
Polar area |
122.09 |
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Complexity |
1248.866646 |
xlogp Value |
3.3572 |
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Heavy Count |
36 |
Rot Bonds |
9 |
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Hbond acc |
6 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
AU2020291014A1 IC-9 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
161.03 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
233.7 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
788 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-14 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-17 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||