Payload Information
General Information of This Payload
| Payload ID | PAY0PMCPL |
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| Name | WO2024043319A1 5 payload |
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| Synonyms |
SCHEMBL27104904; SCHEMBL30781676
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| Structure |
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| Formula | C52H57N9O6 |
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| Isosmiles | CC1(NCC#CC2=CC=C(OC)C(N(CCC3=O)C(N3)=O)=C2)CCN(CC1)C4CCN(CC4)C5=NC(C(C6=CC=CC=C6)(OC7CC7)CO)=C8C=C(C(C9=C%10NC=C9)=CN(C)C%10=O)C=CC8=N5 |
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| InChI |
InChI=1S/C52H57N9O6/c1-51(54-23-7-8-34-11-16-44(66-3)43(30-34)61-27-20-45(63)56-50(61)65)21-28-59(29-22-51)37-18-25-60(26-19-37)49-55-42-15-12-35(41-32-58(2)48(64)46-39(41)17-24-53-46)31-40(42)47(57-49)52(33-62,67-38-13-14-38)36-9-5-4-6-10-36/h4-6,9-12,15-17,24,30-32,37-38,53-54,62H,13-14,18-23,25-29,33H2,1-3H3,(H,56,63,65)
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| InChIKey |
CWIZHMDTDKAALC-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
904.085 |
Polar area |
170.18 |
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Complexity |
2890.845972 |
xlogp Value |
5.8112 |
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Heavy Count |
67 |
Rot Bonds |
12 |
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Hbond acc |
12 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 0.015 nM | Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||
WO2024043319A1 5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.035 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||