Payload Information

General Information of This Payload

Payload ID	PAY0OCUAW
Name	GRM cpd 24
Synonyms	GRM cpd 24 Click to Show/Hide
Target(s)	Glucocorticoid receptor (NR3C1)			Target Info
Structure
Structure	3D MOL		2D MOL
Formula	C33H35NO6S
Isosmiles	CC12C=CC(=O)C=C1CCC1C3CC4OC(c5ccc(Sc6cccc(N)c6)cc5)OC4(C(=O)CO)C3CC(O)C12
InChI	InChI=1S/C33H35NO6S/c1-32-12-11-21(36)13-19(32)7-10-24-25-15-29-33(28(38)17-35,26(25)16-27(37)30(24)32)40-31(39-29)18-5-8-22(9-6-18)41-23-4-2-3-20(34)14-23/h2-6,8-9,11-14,24-27,29-31,35,37H,7,10,15-17,34H2,1H3
InChIKey	HSDZRTSJENIXOM-UHFFFAOYSA-N
Pharmaceutical Properties	Molecule Weight	573.711	Polar area	119.08
	Complexity	41	xlogp Value	4.6327
	Heavy Count	41	Rot Bonds	5
	Hbond acc	8	Hbond Donor	3

The activity data of This Payload

Standard Type	Value	Units	Cell line	Disease Model	Cell line ID	Reference
Glucocorticoid response element reporter EC50	0.0017	uM	Undisclosed	Undisclosed	Undisclosed	[1]
Glucocorticoid Receptor binding IC50	0.012	uM	Undisclosed	Undisclosed	Undisclosed	[1]

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Anti-TNF ADC 112 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[2]
Efficacy Data	Half Maximal Effective Concentration (EC50)	0.38 ug/mL	Positive TNF expression (TNF+++/++)
Method Description	All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
In Vitro Model	Chronic myelogenous leukemia	K-562 cells (TNF expression)		CVCL_0004
Experiment 2 Reporting the Activity Date of This ADC					[2]
Efficacy Data	Half Maximal Effective Concentration (EC50)	6.40 ug/mL	Negative TNF expression (TNF-)
Method Description	All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
In Vitro Model	Chronic myelogenous leukemia	K-562 cells		CVCL_0004

References

Ref 1	Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.
Ref 2	Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.