Payload Information
General Information of This Payload
| Payload ID | PAY0NNEQK |
|||||
|---|---|---|---|---|---|---|
| Name | ER-001150828 |
|||||
| Synonyms |
ER-001150828
Click to Show/Hide
|
|||||
| Structure |
|
|||||
| Formula | C32H44ClN3O9 |
|||||
| Isosmiles | C[C@]([C@@H]1/C=C/[C@@H](OC)[C@](O)(NC(O2)=O)C[C@@]2([H])[C@@H](C)[C@H](O3)[C@]3(C)[C@@H](OC(C(C)C)=O)CC4=O)(N1)CC5=CC(OC)=C(Cl)C(N4C)=C5 |
|||||
| InChI |
InChI=1S/C32H44ClN3O9/c1-16(2)28(38)44-24-13-25(37)36(6)19-11-18(12-20(41-7)26(19)33)14-30(4)22(34-30)9-10-23(42-8)32(40)15-21(43-29(39)35-32)17(3)27-31(24,5)45-27/h9-12,16-17,21-24,27,34,40H,13-15H2,1-8H3,(H,35,39)/t17-,21+,22+,23-,24+,27+,30+,31+,32+/m1/s1
|
|||||
| InChIKey |
CKYCATCIONYFNF-GJBBEJBUSA-N
|
|||||
| Pharmaceutical Properties | Molecule Weight |
650.169 |
Polar area |
158.1 |
||
Complexity |
1384.604977 |
xlogp Value |
3.1078 |
|||
Heavy Count |
45 |
Rot Bonds |
4 |
|||
Hbond acc |
10 |
Hbond Donor |
3 |
|||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
MORAb-003 ADC6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
|
||||
| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||
MORAb-003 ADC7 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
|
||||
| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||