Payload Information
General Information of This Payload
| Payload ID | PAY0NCDKY |
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| Name | US20250000991A1 Ab1 ADC Payload |
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| Synonyms |
US20250000991A1 Ab1 ADC Payload
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| Structure |
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| Formula | C24H22FN3O6 |
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| Isosmiles | CC1=CC(C(CNC(CO)=O)=C(C(C2=CC([C@@]3(O)CC)=C4COC3=O)=N5)CN2C4=O)=C5C=C1F |
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| InChI |
InChI=1S/C24H22FN3O6/c1-3-24(33)16-5-19-21-14(8-28(19)22(31)15(16)10-34-23(24)32)13(7-26-20(30)9-29)12-4-11(2)17(25)6-18(12)27-21/h4-6,29,33H,3,7-10H2,1-2H3,(H,26,30)/t24-/m0/s1
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| InChIKey |
PNQVPNNKOJPFOJ-DEOSSOPVSA-N
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| Pharmaceutical Properties | Molecule Weight |
467.453 |
Polar area |
130.75 |
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Complexity |
1421.139497 |
xlogp Value |
1.13562 |
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Heavy Count |
34 |
Rot Bonds |
4 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
US20250000991A1 Ab1 ADC [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.0766 nM
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High Nectin-4 expression (Nectin-4 +++) | ||
| Method Description |
Ab5 ADC was tested in T24 mScarlet clone 5 nectin-4 negative cells ;and with a DAR of 8
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| In Vitro Model | Bladder carcinoma | T24 mScarlet clone 5 nectin-4 negative cells | CVCL_0554 | ||