Payload Information
General Information of This Payload
| Payload ID | PAY0LSCPY |
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|---|---|---|---|---|---|---|
| Name | CL202203715A1 P11 |
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| Synonyms |
CL202203715A1 P11
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| Structure |
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| Formula | C45H72FN5O7S |
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| Isosmiles | C=O.CCCCCCN(C([C@@H](NC([C@H]1CCCCN1C)=O)[C@H](CC)C)=O)[C@@H](C(C)C)C[C@@H](OCC)C2=NC(C(N[C@@H](CC3=CC=C(F)C=C3)CC(C)(C)C(O)=O)=O)=CS2 |
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| InChI |
InChI=1S/C44H70FN5O6S.CH2O/c1-10-13-14-16-24-50(42(53)38(30(6)11-2)48-40(52)35-18-15-17-23-49(35)9)36(29(4)5)26-37(56-12-3)41-47-34(28-57-41)39(51)46-33(27-44(7,8)43(54)55)25-31-19-21-32(45)22-20-31;1-2/h19-22,28-30,33,35-38H,10-18,23-27H2,1-9H3,(H,46,51)(H,48,52)(H,54,55);1H2/t30-,33-,35+,36+,37+,38-;/m0./s1
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| InChIKey |
HEYZMJQYFYEXSA-DTXSHLFSSA-N
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| Pharmaceutical Properties | Molecule Weight |
846.164 |
Polar area |
158.24 |
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Complexity |
1519.588452 |
xlogp Value |
7.8557 |
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Heavy Count |
59 |
Rot Bonds |
24 |
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Hbond acc |
9 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TRSQ-ZP3A-LP21 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.232 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 26% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A-LP20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.366 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 25% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||