Payload Information
General Information of This Payload
| Payload ID | PAY0LHWMS |
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| Name | US12209180B2 P6 |
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| Synonyms |
P6
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| Structure |
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| Formula | C40H57N5O3 |
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| Isosmiles | C[C@]12CCC[C@](C)(C(NC([C@]3(C)[C@]4([H])CCC(C=CC(N)=C5)=C5[C@]4(CCC3)C)=O)=O)[C@]1([H])CCC6=C2C=C(NC([C@H](CCCCN)N)=O)C=C6 |
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| InChI |
InChI=1S/C40H57N5O3/c1-37-18-7-20-39(3,32(37)16-12-25-10-14-27(42)23-29(25)37)35(47)45-36(48)40(4)21-8-19-38(2)30-24-28(15-11-26(30)13-17-33(38)40)44-34(46)31(43)9-5-6-22-41/h10-11,14-15,23-24,31-33H,5-9,12-13,16-22,41-43H2,1-4H3,(H,44,46)(H,45,47,48)/t31-,32+,33+,37+,38+,39-,40-/m0/s1
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| InChIKey |
IOGVKFDMGWOALJ-SURQHERUSA-N
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| Pharmaceutical Properties | Molecule Weight |
655.928 |
Polar area |
153.33 |
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Complexity |
1651.726664 |
xlogp Value |
6.0272 |
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Heavy Count |
48 |
Rot Bonds |
8 |
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Hbond acc |
6 |
Hbond Donor |
5 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
H1H21234N-N297Q-LP9 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.414 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
H1H21234N-N297Q-LP10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.96 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||