Payload Information

General Information of This Payload

Payload ID	PAY0LBHJQ
Name	siCPT1C
Synonyms	siCPT1C Click to Show/Hide
Target(s)	Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

2-DG/aV-siCPT1C [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.10 ug/mL	Positive VEGFR2 expression (VEGFR2 +++/++)
Method Description	The Cell Counting Kit-8 (CCK8) method was used to detect the effect of nanocapsules on cell viability. The cultured U87 and HA1800 cells were placed in a 96-well plate at a density of 5 x 10³ cells/well. After 24 h of culture, PBS, 2-DG/aV-siCPT1C NC were added.
In Vitro Model	Glioblastoma	U-87MG cells		CVCL_0022

References

Ref 1	Cascade-Responsive 2-DG Nanocapsules Encapsulate aV-siCPT1C Conjugates to Inhibit Glioblastoma through Multiple Inhibition of Energy Metabolism. ACS Appl Mater Interfaces. 2023 Mar 1;15(8):10356-10370. doi: 10.1021/acsami.2c19285. Epub 2023 Feb 14.

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