Payload Information

General Information of This Payload

Payload ID	PAY0KDKZT
Name	Quinoin
Synonyms	Quinoin Click to Show/Hide
Target(s)	Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Quinoin cetuximab immunoconjugate [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	27.70 nM	Positive EGFR expression (EGFR +++/++)
Method Description	Cells were treated with different concentrations of drugs for 72 h. The viability was determined using the MTT assay.
In Vitro Model	Colon carcinoma	GEO cells (Cetuximab-resistant)		CVCL_0271

References

Ref 1	A Novel EGFR Targeted Immunotoxin Based on Cetuximab and Type 1 RIP Quinoin Overcomes the Cetuximab Resistance in Colorectal Cancer Cells. Toxins (Basel). 2023 Jan 9;15(1):57. doi: 10.3390/toxins15010057.

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