Payload Information

General Information of This Payload

Payload ID	PAY0KDADU
Name	Tolllike receptor 7 agonist
Synonyms	Tolllike receptor 7 agonist Click to Show/Hide
Target(s)	Toll-like receptor 7 (TLR7)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

NJH-395 [Phase 1]

ADC Info

Identified from the Human Clinical Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Objective Response Rate (ORR)	0.00%
Patients Enrolled	Patients with nonbreast HER2+ advanced malignancies.
Administration Dosage	5 dose cohorts (0.10-1.60 mg/kg).
*Related Clinical Trial*
NCT Number	NCT03696771	Phase Status	Phase 1
Clinical Description	A phase 1, multicenter, open-label dose finding study of NJH395, administered intravenously in patients with non-breast HER2+ advanced malignancies.

References

Ref 1	Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer. Clin Cancer Res. 2020 Jan 15;26(2):364-372. doi: 10.1158/1078-0432.CCR-18-3965.

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