Payload Information

General Information of This Payload

Payload ID	PAY0JBVNE
Name	GRM cpd 22
Synonyms	GRM cpd 22 Click to Show/Hide
Target(s)	Glucocorticoid receptor (NR3C1)			Target Info
Structure
Structure	3D MOL		2D MOL
Formula	C33H33F2NO6S
Isosmiles	CC12C=CC(=O)C=C1C(F)CC1C3CC4OC(c5ccc(Sc6ccc(N)cc6)cc5)OC4(C(=O)CO)C3CC(O)C12F
InChI	InChI=1S/C33H33F2NO6S/c1-31-11-10-19(38)12-25(31)26(34)14-24-22-13-29-32(28(40)16-37,23(22)15-27(39)33(24,31)35)42-30(41-29)17-2-6-20(7-3-17)43-21-8-4-18(36)5-9-21/h2-12,22-24,26-27,29-30,37,39H,13-16,36H2,1H3
InChIKey	PEGQAOWBGXGTFD-UHFFFAOYSA-N
Pharmaceutical Properties	Molecule Weight	609.691	Polar area	119.08
	Complexity	43	xlogp Value	4.6728
	Heavy Count	43	Rot Bonds	5
	Hbond acc	8	Hbond Donor	3

The activity data of This Payload

Standard Type	Value	Units	Cell line	Disease Model	Cell line ID	Reference
Glucocorticoid response element reporter EC50	0.0005±0.0006	uM	Undisclosed	Undisclosed	Undisclosed	[1]
Glucocorticoid Receptor binding IC50	0.015±0.013	uM	Undisclosed	Undisclosed	Undisclosed	[1]

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Anti-TNF ADC 110 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[2]
Efficacy Data	Half Maximal Effective Concentration (EC50)	0.19 ug/mL	Positive TNF expression (TNF+++/++)
Method Description	All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
In Vitro Model	Chronic myelogenous leukemia	K-562 cells (TNF expression)		CVCL_0004
Experiment 2 Reporting the Activity Date of This ADC					[2]
Efficacy Data	Half Maximal Effective Concentration (EC50)	2.90 ug/mL	Negative TNF expression (TNF-)
Method Description	All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
In Vitro Model	Chronic myelogenous leukemia	K-562 cells		CVCL_0004

References

Ref 1	Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.
Ref 2	Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.