Payload Information

General Information of This Payload
Payload ID
PAY0ISVPY
Name
Silicon Phthalocyanine
Synonyms
Silicon phthalocyanine; Sipc IV; 135719-28-7; Silicon Phthalocyanine 4; Hosipcosi(CH3)2(CH2)3N(CH3)2; (OC-6-23)-((3-(Dimethylamino)propyl)dimethylsilanolato-O)hydroxy(29H,31H-phthalocyaninato(2-)-N(29),N(30),N(31),N(32))silicon; 3-[dimethyl(oxido)silyl]-N,N-dimethylpropan-1-amine;2,11,20,37,38-pentaza-39,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19,21(38),22,24,26,28,30(37),31,33,35-nonadecaene;silicon(4+);hydroxide; Silicon, ((3-(dimethylamino)propyl)dimethylsilanolato-kappaO)hydroxy(29H,31H-phthalocyaninato(2-)-kappaN29,kappaN30,kappaN31,kappaN32)-, (OC-6-23)-; Silicon, ((3-(dimethylamino)propyl)dimethylsilanolato-O)hydroxy(29H,31H-phthalocyaninato(2-)-N(29),N(30),N(31),N(32))-, (OC-6-23)-; Cl2SiPc; UNII-VM2R9Z8DTW; Silicon phthalocyanine Pc4; C39H35N9O2Si2; DTXSID00159502; C39-H35-N9-O2-Si2; NSC 676418; LS-186965
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Target(s) .
 Target Info 
Structure
Formula
C40H36N8O2Si2
Isosmiles
CN(C)CCC[Si](C)(C)[O-].C1=CC=C2C(=C1)C3=CC4=NC(=NC5=C6C=CC=CC6=C([N-]5)N=C7C8=CC=CC=C8C(=NC2=N3)[N-]7)C9=CC=CC=C94.[OH-].[Si+4]
PubChem CID
119185
InChI
InChI=1S/C33H17N7.C7H18NOSi.H2O.Si/c1-3-11-20-18(9-1)26-17-27-19-10-2-4-12-21(19)29(35-27)37-31-23-14-6-8-16-25(23)33(39-31)40-32-24-15-7-5-13-22(24)30(38-32)36-28(20)34-26;1-8(2)6-5-7-10(3,4)9;;/h1-17H;5-7H2,1-4H3;1H2;/q-2;-1;;+4/p-1
InChIKey
JACPFCQFVIAGDN-UHFFFAOYSA-M
IUPAC Name
3-[dimethyl(oxido)silyl]-N,N-dimethylpropan-1-amine;2,11,20,37,38-pentaza-39,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19,21(38),22,24,26,28,30(37),31,33,35-nonadecaene;silicon(4+);hydroxide
Pharmaceutical Properties
Molecule Weight
716.9
Polar area
93.8
Complexity
939
xlogp Value
.
Heavy Count
52
Rot Bonds
4
Hbond acc
10
Hbond Donor
1
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
ZHER2:342-Cupid-His-Ax-SiPc [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI)
82.40% (Day 21)
Low HER2 expression (HER2+)
Method Description
The Kadcyla (the anti- Her2 ADC) group were administered at 300 g.
In Vivo Model KPL- 4 cell line xenograft model
In Vitro Model Breast inflammatory carcinoma KPL-4 cells CVCL_5310
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI)
93.40% (Day 21)
Low HER2 expression (HER2+)
Method Description
The ZHER2:342-Cupid-His-Ax-SiPc group were administered at 150 g.
In Vivo Model KPL- 4 cell line xenograft model
In Vitro Model Breast inflammatory carcinoma KPL-4 cells CVCL_5310
References
Ref 1 Pathological complete remission of relapsed tumor by photo-activating antibody-mimetic drug conjugate treatment. Cancer Sci. 2022 Dec;113(12):4350-4362.

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