Payload Information
General Information of This Payload
| Payload ID | PAY0INAAA |
|||||
|---|---|---|---|---|---|---|
| Name | US12209180B2 P8 |
|||||
| Synonyms |
P8
Click to Show/Hide
|
|||||
| Structure |
|
|||||
| Formula | C39H52N4O5 |
|||||
| Isosmiles | C[C@]12CCC[C@](C)(C(NC([C@]3(C)[C@]4([H])CCC(C=CC(N)=C5)=C5[C@]4(CCC3)C)=O)=O)[C@]1([H])CCC6=C2C=C(NC([C@H](CCC(O)=O)N)=O)C=C6 |
|||||
| InChI |
InChI=1S/C39H52N4O5/c1-36-17-5-19-38(3,30(36)14-9-23-7-11-25(40)21-27(23)36)34(47)43-35(48)39(4)20-6-18-37(2)28-22-26(12-8-24(28)10-15-31(37)39)42-33(46)29(41)13-16-32(44)45/h7-8,11-12,21-22,29-31H,5-6,9-10,13-20,40-41H2,1-4H3,(H,42,46)(H,44,45)(H,43,47,48)/t29-,30+,31+,36+,37+,38-,39-/m0/s1
|
|||||
| InChIKey |
BFPHSVPNUSNFDO-RIZDYJGBSA-N
|
|||||
| Pharmaceutical Properties | Molecule Weight |
656.868 |
Polar area |
164.61 |
||
Complexity |
1714.947743 |
xlogp Value |
5.763 |
|||
Heavy Count |
48 |
Rot Bonds |
7 |
|||
Hbond acc |
6 |
Hbond Donor |
5 |
|||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
H1H21234N-N297Q-LP11 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.978 nM
|
Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
|
||||
| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||