Payload Information
General Information of This Payload
| Payload ID | PAY0IECSD |
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| Name | WO2024020536A1+HER-E-48+payload |
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| Synonyms |
WO2024020536A1+HER-E-48+payload
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| Structure |
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| Formula | C24H21FN2O5 |
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| Isosmiles | O[C@]1(CC)C(C=C2C3=NC4=CC(F)=C(C)C5=C4C(C(O)CC5)=C3CN62)=C(COC1=O)C6=O |
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| InChI |
InChI=1S/C24H21FN2O5/c1-3-24(31)14-6-17-21-12(8-27(17)22(29)13(14)9-32-23(24)30)20-18(28)5-4-11-10(2)15(25)7-16(26-21)19(11)20/h6-7,18,28,31H,3-5,8-9H2,1-2H3/t18?,24-/m1/s1
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| InChIKey |
FRPSGSHVDGIPFA-VCUSLETLSA-N
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| Pharmaceutical Properties | Molecule Weight |
436.439 |
Polar area |
101.65 |
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Complexity |
1406.93979 |
xlogp Value |
2.50672 |
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Heavy Count |
32 |
Rot Bonds |
1 |
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Hbond acc |
7 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
HER-E-48 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
109.2 pM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A Cell line test on SKBR-3
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||