Payload Information
General Information of This Payload
| Payload ID | PAY0HDVOT |
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|---|---|---|---|---|---|---|
| Name | CN115429893A ADC2 Payload |
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| Synonyms |
CN115429893A ADC2
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| Structure |
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| Formula | C24H19F2N3O6 |
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| Isosmiles | FC(C(F)=C1)=C2CC[C@H](NC(O)=O)C3=C2C1=NC(C4=CC([C@@]5(O)CC)=C6COC5=O)=C3CN4C6=O |
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| InChI |
InChI=1S/C24H19F2N3O6/c1-2-24(34)12-5-16-20-10(7-29(16)21(30)11(12)8-35-22(24)31)18-14(28-23(32)33)4-3-9-17(18)15(27-20)6-13(25)19(9)26/h5-6,14,28,34H,2-4,7-8H2,1H3,(H,32,33)/t14-,24-/m0/s1
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| InChIKey |
KDJLLENMTSNHQN-BSEYFRJRSA-N
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| Pharmaceutical Properties | Molecule Weight |
483.427 |
Polar area |
130.75 |
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Complexity |
1518.594434 |
xlogp Value |
2.6127 |
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Heavy Count |
35 |
Rot Bonds |
2 |
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Hbond acc |
7 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
CN115429893A ADC2 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
98.53%
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
In the SKOV3 xenograft model, the ADCs were administered at 5 mg/kg (once, IV).
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| In Vivo Model | SKOV3 xenograft model | ||||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
98.53%
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
In the SKOV3 xenograft model, the ADCs were administered at 5 mg/kg (once, IV).
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| In Vivo Model | SKOV3 xenograft model | ||||