Payload Information

General Information of This Payload
Payload ID
PAY0GNSZP
Name
Eosin Y
Synonyms
Eosin Y
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Formula
C20H8Br4O5
Isosmiles
OC1=C(Br)C=C(C(C(C=CC=C2)=C2C(O)=O)=C3C(O4)=C(Br)C(C(Br)=C3)=O)C4=C1Br
PubChem CID
11049
InChI
InChI=1S/C20H8Br4O5/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25/h1-6,25H,(H,27,28)
InChIKey
AZXGXVQWEUFULR-UHFFFAOYSA-N
Pharmaceutical Properties
Molecule Weight
647.895
Polar area
87.74
Complexity
1324.861359
xlogp Value
7.0186
Heavy Count
29
Rot Bonds
2
Hbond acc
4
Hbond Donor
2
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Cell-based Percent Inhibition (%) -161 % Undisclosed Undisclosed Undisclosed
Cell-based Potency 100 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 10000 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 10000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 1400 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Activity Concentration (AC50) 15848.9 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 17769.3 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 180 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Potency 19905.4 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 19952.6 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 22387.2 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 22387.2 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 22387.2 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 25118.9 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 2787000 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 28183.8 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 28183.8 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 28183.8 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >300000 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 31622.8 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 31622.8 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 3548.1 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 35481.3 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 35481.3 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 36125.4 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Potency 40533.4 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 406 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 4466.8 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 5031.5 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 562.3 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 56234.1 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 633.4 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 707.9 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 707.9 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 7568.6 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 7689.3 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 794.3 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 79432.8 nM Undisclosed Undisclosed Undisclosed
Cell-based Potency 8912.5 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 15.85 uM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 4.467 uM Undisclosed Undisclosed Undisclosed
Each Antibody-drug Conjugate Related to This Payload