Payload Information
General Information of This Payload
| Payload ID | PAY0GBCSS |
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|---|---|---|---|---|---|---|
| Name | WO2024140449A1+ADC1+payload |
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| Synonyms |
WO2024140449A1+ADC1+payload
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| Formula | C36H36N4O9 |
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| Isosmiles | CC[C@]1(O)C(C=C2C3=NC4=CC5=C(OCO5)C=C4C(CCN(C6CCOCC6)C(OCC7=CC=C(N)C=C7)=O)=C3CN82)=C(COC1=O)C8=O |
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| InChI |
InChI=1S/C36H36N4O9/c1-2-36(44)27-14-29-32-25(16-40(29)33(41)26(27)18-46-34(36)42)23(24-13-30-31(49-19-48-30)15-28(24)38-32)7-10-39(22-8-11-45-12-9-22)35(43)47-17-20-3-5-21(37)6-4-20/h3-6,13-15,22,44H,2,7-12,16-19,37H2,1H3/t36-/m0/s1
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| InChIKey |
PXYUTWQKPCTAKG-BHVANESWSA-N
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| Pharmaceutical Properties | Molecule Weight |
668.703 |
Polar area |
164.67 |
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Complexity |
2002.564963 |
xlogp Value |
3.7508 |
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Heavy Count |
49 |
Rot Bonds |
7 |
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Hbond acc |
12 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
wO2024140449A1 ADC1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||