Payload Information
General Information of This Payload
| Payload ID | PAY0FYDEQ |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 20 payload |
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| Synonyms |
PAY0444
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| Structure |
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| Formula | C53H59N9O6 |
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| Isosmiles | CN1C(C2=C(C(C(C=CC3=NC(N4CCC(N5CCC(C)(NCC#CC6=CC=C(OC)C(N(C7=O)CCC(N7C)=O)=C6)CC5)CC4)=N8)=CC3=C8[C@@](CO)(OC9CC9)C%10=CC=CC=C%10)=C1)C=CN2)=O |
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| InChI |
InChI=1S/C53H59N9O6/c1-52(55-24-8-9-35-12-17-45(67-4)44(31-35)62-28-21-46(64)59(3)51(62)66)22-29-60(30-23-52)38-19-26-61(27-20-38)50-56-43-16-13-36(42-33-58(2)49(65)47-40(42)18-25-54-47)32-41(43)48(57-50)53(34-63,68-39-14-15-39)37-10-6-5-7-11-37/h5-7,10-13,16-18,25,31-33,38-39,54-55,63H,14-15,19-24,26-30,34H2,1-4H3/t53-/m0/s1
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| InChIKey |
ZWLVKFBXULZJLF-DTSDQNDWSA-N
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| Pharmaceutical Properties | Molecule Weight |
918.112 |
Polar area |
161.39 |
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Complexity |
2927.224522 |
xlogp Value |
6.1534 |
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Heavy Count |
68 |
Rot Bonds |
12 |
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Hbond acc |
12 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.035 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||