Payload Information
General Information of This Payload
| Payload ID | PAY0FWIZS |
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|---|---|---|---|---|---|---|
| Name | ADC-4 Payload |
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| Synonyms |
ADC-4 Payload
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| Structure |
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| Formula | C26H29N3O4 |
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| Isosmiles | CC(N(CCC(C1=CC=CC=C1N=C2C3=CC([C@]4(CC)O)=C5COC4=O)=C2CN3C5=O)C)C |
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| InChI |
InChI=1S/C26H29N3O4/c1-5-26(32)20-12-22-23-18(13-29(22)24(30)19(20)14-33-25(26)31)16(10-11-28(4)15(2)3)17-8-6-7-9-21(17)27-23/h6-9,12,15,32H,5,10-11,13-14H2,1-4H3/t26-/m0/s1
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| InChIKey |
DHLMSSPUJZLOQQ-SANMLTNESA-N
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| Pharmaceutical Properties | Molecule Weight |
447.535 |
Polar area |
84.66 |
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Complexity |
1312.098224 |
xlogp Value |
2.9623 |
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Heavy Count |
33 |
Rot Bonds |
5 |
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Hbond acc |
7 |
Hbond Donor |
1 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2025019787A1 ADC-8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.318 nM
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Positive huROR1 expression (huROR1+++/++) | ||
| Method Description |
ADC-8 was tested in HEK293-huROR1 cells, starting with a top concentration of 60 nM (4x the final top concentration),each of the samples was serially diluted 5 times (1:4 for ADC-8), 5 days.
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| In Vitro Model | Normal | HEK293-huROR1 cells | CVCL_0045 | ||
References