Payload Information
General Information of This Payload
| Payload ID | PAY0FKBCN |
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| Name | WO2024140449A1+ADC13+payload |
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| Synonyms |
WO2024140449A1+ADC13+payload
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| Formula | C35H34N4O9 |
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| Isosmiles | CC[C@]1(O)C(C=C2C3=NC4=CC5=C(OCO5)C=C4C(CCN(C(OCC6=CC=C(N)C=C6)=O)[C@@H]7CCOC7)=C3CN82)=C(COC1=O)C8=O |
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| InChI |
InChI=1S/C35H34N4O9/c1-2-35(43)26-12-28-31-24(14-39(28)32(40)25(26)17-45-33(35)41)22(23-11-29-30(48-18-47-29)13-27(23)37-31)7-9-38(21-8-10-44-16-21)34(42)46-15-19-3-5-20(36)6-4-19/h3-6,11-13,21,43H,2,7-10,14-18,36H2,1H3/t21-,35+/m1/s1
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| InChIKey |
TTZCPUGQZXDRNB-QGFSVNGOSA-N
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| Pharmaceutical Properties | Molecule Weight |
654.676 |
Polar area |
164.67 |
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Complexity |
1985.287604 |
xlogp Value |
3.3607 |
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Heavy Count |
48 |
Rot Bonds |
7 |
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Hbond acc |
12 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
wO2024140449A1 ADC13 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC16 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC14 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
50-500 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||