Payload Information
General Information of This Payload
| Payload ID | PAY0FCRSD |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 21 payload |
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| Synonyms |
PAY0445
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| Structure |
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| Formula | C52H57N9O8 |
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| Isosmiles | CN1C(C2=C(C(C(C=CC3=NC(N4CCC(N5CCC(C)(NCC#CC6=CC=C(OC)C(N(CCC7=O)C(N7)=O)=C6)CC5)CC4)=N8)=CC3=C8[C@@](CO)(OC9CC9)C%10=CC=CC=C%10)=C1)C=CN2)=O.[O].[O] |
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| InChI |
InChI=1S/C52H57N9O6.2O/c1-51(54-23-7-8-34-11-16-44(66-3)43(30-34)61-27-20-45(63)56-50(61)65)21-28-59(29-22-51)37-18-25-60(26-19-37)49-55-42-15-12-35(41-32-58(2)48(64)46-39(41)17-24-53-46)31-40(42)47(57-49)52(33-62,67-38-13-14-38)36-9-5-4-6-10-36;;/h4-6,9-12,15-17,24,30-32,37-38,53-54,62H,13-14,18-23,25-29,33H2,1-3H3,(H,56,63,65);;/t52-;;/m0../s1
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| InChIKey |
XEGDCJGQTXNOFL-OPCIFKNZSA-N
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| Pharmaceutical Properties | Molecule Weight |
936.083 |
Polar area |
227.18 |
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Complexity |
2890.845972 |
xlogp Value |
5.5736 |
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Heavy Count |
69 |
Rot Bonds |
12 |
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Hbond acc |
12 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 21 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.061 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||