Payload Information
General Information of This Payload
| Payload ID | PAY0ETZSE |
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|---|---|---|---|---|---|---|
| Name | CL202203715A1 P47 |
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| Synonyms |
CL202203715A1 P47
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| Structure |
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| Formula | C51H78FN7O8S2 |
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| Isosmiles | CCCCCCN(C(C[C@@H](C)CC)=O)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(F)C=C2)CC(C)(C)C(NS(C3=CC=C(N)C=C3)(=O)=O)=O)=O)=CS1.CN4CCCC[C@@H]4C(NC)=O |
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| InChI |
InChI=1S/C43H62FN5O7S2.C8H16N2O/c1-9-11-12-13-22-49(39(51)23-29(5)10-2)37(28(3)4)25-38(56-30(6)50)41-47-36(27-57-41)40(52)46-34(24-31-14-16-32(44)17-15-31)26-43(7,8)42(53)48-58(54,55)35-20-18-33(45)19-21-35;1-9-8(11)7-5-3-4-6-10(7)2/h14-21,27-29,34,37-38H,9-13,22-26,45H2,1-8H3,(H,46,52)(H,48,53);7H,3-6H2,1-2H3,(H,9,11)/t29-,34-,37+,38+;7-/m01/s1
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| InChIKey |
JOPNURIJELIYNG-RVDRQRPNSA-N
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| Pharmaceutical Properties | Molecule Weight |
1000.358 |
Polar area |
210.2 |
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Complexity |
2133.742629 |
xlogp Value |
8.2076 |
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Heavy Count |
69 |
Rot Bonds |
24 |
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Hbond acc |
12 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TRSQ-ZP3A-LP24 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
2.733 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 30% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
CTRL-ZP3A-LP24 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
321.547 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 31% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||