Payload Information

General Information of This Payload

Payload ID	PAY0EDJXK
Name	GRM cpd 63
Synonyms	GRM cpd 63 Click to Show/Hide
Target(s)	Glucocorticoid receptor (NR3C1)			Target Info
Structure
Structure	3D MOL		2D MOL
Formula	C35H37F2NO6
Isosmiles	CC(c1ccc(C2OC3CC4C(CC(O)C5(F)C4CC(F)C4=CC(=O)C=CC45C)C3(C(=O)CO)O2)cc1)c1cccc(N)c1
InChI	InChI=1S/C35H37F2NO6/c1-18(21-4-3-5-22(38)12-21)19-6-8-20(9-7-19)32-43-31-14-24-25(34(31,44-32)30(42)17-39)16-29(41)35(37)26(24)15-28(36)27-13-23(40)10-11-33(27,35)2/h3-13,18,24-26,28-29,31-32,39,41H,14-17,38H2,1-2H3
InChIKey	TXDLLWDVUPWMTK-UHFFFAOYSA-N
Pharmaceutical Properties	Molecule Weight	605.678	Polar area	119.08
	Complexity	44	xlogp Value	4.6734
	Heavy Count	44	Rot Bonds	5
	Hbond acc	7	Hbond Donor	3

The activity data of This Payload

Standard Type	Value	Units	Cell line	Disease Model	Cell line ID	Reference
Glucocorticoid response element reporter EC50	0.0007	uM	Undisclosed	Undisclosed	Undisclosed	[1]
Glucocorticoid Receptor binding IC50	0.011	uM	Undisclosed	Undisclosed	Undisclosed	[1]

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Anti-TNF ADC 135 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[2]
Efficacy Data	Half Maximal Effective Concentration (EC50)	0.03 ug/mL	Positive TNF expression (TNF+++/++)
Method Description	All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
In Vitro Model	Chronic myelogenous leukemia	K-562 cells (TNF expression)		CVCL_0004
Experiment 2 Reporting the Activity Date of This ADC					[2]
Efficacy Data	Half Maximal Effective Concentration (EC50)	12.00 ug/mL	Negative TNF expression (TNF-)
Method Description	All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
In Vitro Model	Chronic myelogenous leukemia	K-562 cells		CVCL_0004

References

Ref 1	Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.
Ref 2	Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.