Payload Information
General Information of This Payload
| Payload ID | PAY0EACJE |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 22 payload |
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| Synonyms |
PAY0446
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| Structure |
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| Formula | C51H53N9O6 |
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| Isosmiles | CN(C=C(C1=CC(C([C@](C2=CC=CC=C2)(OC3CC3)CO)=NC(N4CCC(N(CC/5)CCC5=N\CC#CC6=CC=C(OC)C(N(C7=O)CCC(N7)=O)=C6)CC4)=N8)=C8C=C1)C9=C%10NC=C9)C%10=O |
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| InChI |
InChI=1S/C51H53N9O6/c1-57-31-41(39-16-23-53-46(39)48(57)63)34-11-14-42-40(30-34)47(51(32-61,66-38-12-13-38)35-8-4-3-5-9-35)56-49(54-42)59-26-19-37(20-27-59)58-24-17-36(18-25-58)52-22-6-7-33-10-15-44(65-2)43(29-33)60-28-21-45(62)55-50(60)64/h3-5,8-11,14-16,23,29-31,37-38,53,61H,12-13,17-22,24-28,32H2,1-2H3,(H,55,62,64)/t51-/m0/s1
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| InChIKey |
PLIMOGOKOLPXPB-XHIZWQFQSA-N
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| Pharmaceutical Properties | Molecule Weight |
888.042 |
Polar area |
170.51 |
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Complexity |
2903.028074 |
xlogp Value |
5.9039 |
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Heavy Count |
66 |
Rot Bonds |
11 |
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Hbond acc |
12 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 22 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
1.6 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||