Payload Information
General Information of This Payload
| Payload ID | PAY0DABTO |
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| Name | WO2024020536A1+HER-E-36+payload |
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| Synonyms |
WO2024020536A1+HER-E-36+payload
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| Structure |
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| Formula | C25H24FN3O5 |
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| Isosmiles | CC[C@@](C(C=C1C2=NC3=CC(F)=C(C)C4=C3C(C(OCN)CC4)=C2CN51)=C(C5=O)CO6)(O)C6=O |
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| InChI |
InChI=1S/C25H24FN3O5/c1-3-25(32)15-6-18-22-13(8-29(18)23(30)14(15)9-33-24(25)31)21-19(34-10-27)5-4-12-11(2)16(26)7-17(28-22)20(12)21/h6-7,19,32H,3-5,8-10,27H2,1-2H3/t19?,25-/m0/s1
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| InChIKey |
HYFZHSIIQOPQPF-BIAFCPFJSA-N
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| Pharmaceutical Properties | Molecule Weight |
465.481 |
Polar area |
116.67 |
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Complexity |
1439.85557 |
xlogp Value |
2.44722 |
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Heavy Count |
34 |
Rot Bonds |
3 |
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Hbond acc |
8 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
HER-E-36 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
790.08 pM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A Cell line test on SKBR-3
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||