Payload Information
General Information of This Payload
| Payload ID | PAY0CWKIQ |
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|---|---|---|---|---|---|---|
| Name | CL202203715A1 P1 |
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| Synonyms |
CL202203715A1 P1
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| Structure |
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| Formula | C42H67FN6O6S |
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| Isosmiles | CCCCCCN(C([C@@H](NC([C@H]1CCCCN1C)=O)[C@H](CC)C)=O)[C@@H](C(C)C)C[C@@H](O)C2=NC(C(N[C@@H](CC3=CC=C(N)C(F)=C3)CC(C)(C)C(O)=O)=O)=CS2 |
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| InChI |
InChI=1S/C42H67FN6O6S/c1-9-11-12-14-20-49(40(53)36(27(5)10-2)47-38(52)33-16-13-15-19-48(33)8)34(26(3)4)23-35(50)39-46-32(25-56-39)37(51)45-29(24-42(6,7)41(54)55)21-28-17-18-31(44)30(43)22-28/h17-18,22,25-27,29,33-36,50H,9-16,19-21,23-24,44H2,1-8H3,(H,45,51)(H,47,52)(H,54,55)/t27-,29-,33+,34+,35+,36-/m0/s1
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| InChIKey |
VKRYZPAOZAQHJW-FJZPGOKQSA-N
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| Pharmaceutical Properties | Molecule Weight |
803.099 |
Polar area |
178.19 |
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Complexity |
1535.083565 |
xlogp Value |
6.5786 |
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Heavy Count |
56 |
Rot Bonds |
22 |
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Hbond acc |
9 |
Hbond Donor |
5 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TRSQ-ZP3A-LP11 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.083 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 16% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A-LP10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.591 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 17% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||