Payload Information
General Information of This Payload
| Payload ID | PAY0CDVCR |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 15 payload |
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| Synonyms |
PAY0439
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| Structure |
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| Formula | C51H55N9O6 |
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| Isosmiles | CN(C=C(C1=CC=C2C(C([C@](C3=CC=CC=C3)(OC4CC4)CO)=NC(N5CCC(N6CCC(NCC#CC7=CC=C(OC)C(N(CCC8=O)C(N8)=O)=C7)CC6)CC5)=N2)=C1)C9=C%10NC=C9)C%10=O |
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| InChI |
InChI=1S/C51H55N9O6/c1-57-31-41(39-16-23-53-46(39)48(57)63)34-11-14-42-40(30-34)47(51(32-61,66-38-12-13-38)35-8-4-3-5-9-35)56-49(54-42)59-26-19-37(20-27-59)58-24-17-36(18-25-58)52-22-6-7-33-10-15-44(65-2)43(29-33)60-28-21-45(62)55-50(60)64/h3-5,8-11,14-16,23,29-31,36-38,52-53,61H,12-13,17-22,24-28,32H2,1-2H3,(H,55,62,64)/t51-/m0/s1
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| InChIKey |
MNZUWXXPMMNJOJ-XHIZWQFQSA-N
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| Pharmaceutical Properties | Molecule Weight |
890.058 |
Polar area |
170.18 |
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Complexity |
2838.386463 |
xlogp Value |
5.4211 |
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Heavy Count |
66 |
Rot Bonds |
12 |
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Hbond acc |
12 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 15 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.039 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||