Payload Information
General Information of This Payload
| Payload ID | PAY0BXRGZ |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 44 payload |
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| Synonyms |
PAY0468
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| Structure |
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| Formula | C60H69N13O10 |
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| Isosmiles | CN(C=C(C1=CC(C([C@@](CO)(OC2CC2)C3=CC=CC=C3)=NC(N4CCC(N5CCC(NCC#CC6=CC=C(OC)C(N(CCC7=O)C(N7CNC(CNC([C@@H](NC(C)=O)CC(N)=O)=O)=O)=O)=C6)CC5)CC4)=N8)=C8C=C1)C9=C%10NC=C9)C%10=O |
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| InChI |
InChI=1S/C60H69N13O10/c1-37(75)66-48(32-51(61)76)56(79)64-33-52(77)65-36-73-53(78)22-29-72(59(73)81)49-30-38(11-16-50(49)82-3)8-7-23-62-41-18-25-70(26-19-41)42-20-27-71(28-21-42)58-67-47-15-12-39(46-34-69(2)57(80)54-44(46)17-24-63-54)31-45(47)55(68-58)60(35-74,83-43-13-14-43)40-9-5-4-6-10-40/h4-6,9-12,15-17,24,30-31,34,41-43,48,62-63,74H,13-14,18-23,25-29,32-33,35-36H2,1-3H3,(H2,61,76)(H,64,79)(H,65,77)(H,66,75)/t48-,60-/m0/s1
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| InChIKey |
HEYMUTDPHGPSGA-GHNCRGBHSA-N
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| Pharmaceutical Properties | Molecule Weight |
1132.293 |
Polar area |
291.78 |
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Complexity |
3449.460193 |
xlogp Value |
2.7035 |
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Heavy Count |
83 |
Rot Bonds |
20 |
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Hbond acc |
16 |
Hbond Donor |
7 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 44 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.074 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||